Neurotoxicity of Anaesthetics and Sedatives and Their Influence on Post-Operative Maladaptive Behavioural Disorders in Paediatric Anaesthesia (The Letter)

Abstract

Neurotoxicity of anaesthetics have become one of the most discussed problems in paediatric anaesthesiology. The experimental studies on animal models have shown that the anaesthetics used in general anaesthesia should have an influence on neurodegenerative processes, neuroapoptosis and the irregulated death of the neuronal cells. Because of this fact, scientists are trying to discover the possibilities of how to minimize the adverse effects of anaesthesia and revise the other alternatives of prevention of anaesthesia-induced maladaptive behavioural disorders.

Keywords

• neurotoxicity of anaesthetics
• maladaptive behavioural disorders
• mechanism of neurotoxicity
• post-anaesthesia behavioural changes in children
• future of paediatric anaesthesiology