A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

Guodong Xie; Tommy V. Vo; Gobi Thillainadesan; Sahana Holla; Beibei Zhang; Yiyang Jiang; Mengqi Lv; Zheng Xu; Chongyuan Wang; Vanivilasini Balachandran; Yunyu Shi; Fudong Li; Shiv I. S. Grewal

doi:10.1038/s41467-018-08273-9

Nature Communications (Jan 2019)

A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

Guodong Xie,
Tommy V. Vo,
Gobi Thillainadesan,
Sahana Holla,
Beibei Zhang,
Yiyang Jiang,
Mengqi Lv,
Zheng Xu,
Chongyuan Wang,
Vanivilasini Balachandran,
Yunyu Shi,
Fudong Li,
Shiv I. S. Grewal

Affiliations

Guodong Xie: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Tommy V. Vo: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Gobi Thillainadesan: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Sahana Holla: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Beibei Zhang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Yiyang Jiang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Mengqi Lv: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Zheng Xu: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Chongyuan Wang: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Vanivilasini Balachandran: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Yunyu Shi: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Fudong Li: Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China
Shiv I. S. Grewal: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-018-08273-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal