BJPsych Open (Nov 2021)
Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection
- Urs Heilbronner,
- Fabian Streit,
- Thomas Vogl,
- Fanny Senner,
- Sabrina K. Schaupp,
- Daniela Reich-Erkelenz,
- Sergi Papiol,
- Mojtaba Oraki Kohshour,
- Farahnaz Klöhn-Saghatolislam,
- Janos L. Kalman,
- Maria Heilbronner,
- Katrin Gade,
- Ashley L. Comes,
- Monika Budde,
- Till F. M. Andlauer,
- Heike Anderson-Schmidt,
- Kristina Adorjan,
- Til Stürmer,
- Adrian Loerbroks,
- Manfred Amelang,
- Eric Poisel,
- Jerome Foo,
- Stefanie Heilmann-Heimbach,
- Andreas J. Forstner,
- Franziska Degenhardt,
- Jörg Zimmermann,
- Jens Wiltfang,
- Martin von Hagen,
- Carsten Spitzer,
- Max Schmauss,
- Eva Reininghaus,
- Jens Reimer,
- Carsten Konrad,
- Georg Juckel,
- Fabian U. Lang,
- Markus Jäger,
- Christian Figge,
- Andreas J. Fallgatter,
- Detlef E. Dietrich,
- Udo Dannlowski,
- Bernhardt T. Baune,
- Volker Arolt,
- Ion-George Anghelescu,
- Markus M. Nöthen,
- Stephanie H. Witt,
- Ole A. Andreassen,
- Chi-Hua Chen,
- Peter Falkai,
- Marcella Rietschel,
- Thomas G. Schulze,
- Eva C. Schulte
Affiliations
- Urs Heilbronner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Fabian Streit
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Thomas Vogl
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Fanny Senner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Sabrina K. Schaupp
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Daniela Reich-Erkelenz
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Sergi Papiol
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Mojtaba Oraki Kohshour
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran
- Farahnaz Klöhn-Saghatolislam
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Janos L. Kalman
- ORCiD
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Maria Heilbronner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Katrin Gade
- ORCiD
- Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany
- Ashley L. Comes
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Monika Budde
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany
- Till F. M. Andlauer
- ORCiD
- Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany
- Heike Anderson-Schmidt
- Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany
- Kristina Adorjan
- ORCiD
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Til Stürmer
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA
- Adrian Loerbroks
- Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany
- Manfred Amelang
- Department of Psychology, University of Heidelberg, Germany
- Eric Poisel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Jerome Foo
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Stefanie Heilmann-Heimbach
- Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany
- Andreas J. Forstner
- Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Germany
- Franziska Degenhardt
- Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Germany
- Jörg Zimmermann
- Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Germany
- Jens Wiltfang
- Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany
- Martin von Hagen
- Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Germany
- Carsten Spitzer
- Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Germany
- Max Schmauss
- Department of Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Germany
- Eva Reininghaus
- Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria
- Jens Reimer
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany
- Carsten Konrad
- Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Germany
- Georg Juckel
- ORCiD
- Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany
- Fabian U. Lang
- Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany
- Markus Jäger
- Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany
- Christian Figge
- Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Germany
- Andreas J. Fallgatter
- Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University Tübingen, Germany
- Detlef E. Dietrich
- AMEOS Clinical Center Hildesheim, Germany; and Center for Systems Neuroscience Hannover, Germany
- Udo Dannlowski
- Institute for Translational Psychiatry, University of Münster, Germany
- Bernhardt T. Baune
- Department of Psychiatry, University of Münster, Germany; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Australia; and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia
- Volker Arolt
- Institute for Translational Psychiatry, University of Münster, Germany
- Ion-George Anghelescu
- Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Germany
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany
- Stephanie H. Witt
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Ole A. Andreassen
- NORMENT Centre and KG Jebsen Centre for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Norway; and Division of Mental Health and Addiction, Oslo University Hospital, Norway
- Chi-Hua Chen
- Department of Radiology, University of California, USA
- Peter Falkai
- Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany
- Marcella Rietschel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Thomas G. Schulze
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA; and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Eva C. Schulte
- ORCiD
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany; and Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Germany
- DOI
- https://doi.org/10.1192/bjo.2021.1030
- Journal volume & issue
-
Vol. 7
Abstract
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus. Aims We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection. Method Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data. Results We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10−5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies. Conclusions We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
Keywords