Evaluation of serum oxidative stress levels and antioxidant capacity in prediabetes

Abstract

Prediabetes is a metabolic disorder marked by blood sugar levels that are elevated than usual but not yet high enough to be classified as type 2 diabetes. It is known that raised oxidative stress and insufficient antioxidant status play a role in the pathogenesis of type 1 and type 2 diabetes. In this study, we aimed to measure total oxidative stress and antioxidant status in prediabetic patients and compare them with healthy volunteers. Subjects with prediabetes according to their HbA1c and blood sugar levels in their routine tests were included in the study. The control group consisted of healthy volunteers who visited our clinics for routine health screening and had no health problems. TAS and TOS levels of the groups were compared. Mean TAS and median TOS values ​​were significantly different among study and control groups (p < 0.001 for both). Blood TOS level was a reliable risk factor of prediabetes, taking into account TAS, weight, triglycerides, and GFR. Higher oxidative stress and lower antioxidant levels were found in prediabetic patients compared to healthy ones. Diabetes development and related complications can be prevented by interventions for these markers in serum.

Keywords

• Prediabetes
• Total oxidative stress
• Total antioxidant status
• Type 2 diabetes