Frontiers in Immunology (Feb 2019)

Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

  • Anja ten Brinke,
  • Anja ten Brinke,
  • Marc Martinez-Llordella,
  • Nathalie Cools,
  • Catharien M. U. Hilkens,
  • S. Marieke van Ham,
  • S. Marieke van Ham,
  • S. Marieke van Ham,
  • Birgit Sawitzki,
  • Edward K. Geissler,
  • Giovanna Lombardi,
  • Piotr Trzonkowski,
  • Eva Martinez-Caceres,
  • Eva Martinez-Caceres

DOI
https://doi.org/10.3389/fimmu.2019.00181
Journal volume & issue
Vol. 10

Abstract

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Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

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