Clinical Manifestation, Transmission, Pathogenesis, and Diagnosis of Monkeypox Virus: A Comprehensive Review

Faheem Anwar; Fatima Haider; Sarmir Khan; Ibrar Ahmad; Naveed Ahmed; Muhammad Imran; Summya Rashid; Zhi-Guang Ren; Saadullah Khattak; Xin-Ying Ji

doi:10.3390/life13020522

Life (Feb 2023)

Clinical Manifestation, Transmission, Pathogenesis, and Diagnosis of Monkeypox Virus: A Comprehensive Review

Faheem Anwar,
Fatima Haider,
Sarmir Khan,
Ibrar Ahmad,
Naveed Ahmed,
Muhammad Imran,
Summya Rashid,
Zhi-Guang Ren,
Saadullah Khattak,
Xin-Ying Ji

Affiliations

Faheem Anwar: Department of Biotechnology and Genetic Engineering, Hazara University, Mansehra 21300, Pakistan
Fatima Haider: Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad 44000, Pakistan
Sarmir Khan: Department of Biotechnology and Genetic Engineering, Hazara University, Mansehra 21300, Pakistan
Ibrar Ahmad: Department of Biotechnology and Genetic Engineering, Hazara University, Mansehra 21300, Pakistan
Naveed Ahmed: Department of Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
Muhammad Imran: Institute of Microbiology & Molecular Genetics, University of Punjab, Lahore Campus, Lahore 54000, Pakistan
Summya Rashid: Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia
Zhi-Guang Ren: Institutes of Traditional Chinese Medicine, Henan University, Kaifeng 475004, China
Saadullah Khattak: Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
Xin-Ying Ji: Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China

DOI: https://doi.org/10.3390/life13020522
Journal volume & issue: Vol. 13, no. 2
p. 522

Abstract

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Monkeypox virus is a double-stranded DNA virus species that causes disease in humans and mammals. It is a zoonotic virus belongs the genus Orthopoxviral, the family of Poxviridae, associated with the smallpox virus in many aspects. The first human case of monkeypox was reported throughout the Democratic Republic of Congo in 1970. In April 2022, several cases were recorded in widespread regions of Africa, the Northern and western hemispheres. The current review spotlights taxonomic classification, clinical presentations during infection, and the pathogenicity of the monkeypox virus in humans. Furthermore, the current review also highlights different diagnostics used for virus detection.

Published in Life

ISSN: 2075-1729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science
Website: http://www.mdpi.com/journal/life

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Abstract

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