Molecules (Jun 2021)

4,7-Disubstituted 7<i>H</i>-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus

  • Ruben Soto-Acosta,
  • Eunkyung Jung,
  • Li Qiu,
  • Daniel J. Wilson,
  • Robert J. Geraghty,
  • Liqiang Chen

DOI
https://doi.org/10.3390/molecules26133779
Journal volume & issue
Vol. 26, no. 13
p. 3779

Abstract

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Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative core structure. Overall, we have identified 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs including compounds 1, 8 and 11 as promising antiviral agents against flaviviruses ZIKV and dengue virus (DENV). While the molecular target of these compounds is yet to be elucidated, 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs are new chemotypes in the design of small molecules against flaviviruses, an important group of human pathogens.

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