Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes

Jung-Ung An; Yong-Seok Song; Kyoung-Rok Kim; Yoon-Joo Ko; Do-Young Yoon; Deok-Kun Oh

doi:10.1038/s41467-017-02543-8

Nature Communications (Jan 2018)

Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes

Jung-Ung An,
Yong-Seok Song,
Kyoung-Rok Kim,
Yoon-Joo Ko,
Do-Young Yoon,
Deok-Kun Oh

Affiliations

Jung-Ung An: Department of Integrative Bioscience and Biotechnology, Konkuk University
Yong-Seok Song: Department of Integrative Bioscience and Biotechnology, Konkuk University
Kyoung-Rok Kim: Department of Integrative Bioscience and Biotechnology, Konkuk University
Yoon-Joo Ko: National Center for Inter-University Research Facilities (NCIRF), Seoul National University
Do-Young Yoon: Department of Integrative Bioscience and Biotechnology, Konkuk University
Deok-Kun Oh: Department of Integrative Bioscience and Biotechnology, Konkuk University

DOI: https://doi.org/10.1038/s41467-017-02543-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Hepoxilins (HXs) and trioxilins (TrXs) are lipid metabolites with roles in inflammation and insulin secretion. Here, the authors discover a prokaryotic source of HXs and TrXs, identify the biosynthetic enzymes and heterologously express HXs and TrXs in E. coli.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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