Synthesis of 1,2,3-Triazole Derivatives and <em>in Vitro</em> Antifungal Evaluation on <em>Candida</em> Strains

Abstract

1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1<em>H</em>-1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or <em>click chemistry</em>). Next the<em> in vitro</em> antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different <em>Candida</em> species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl)-1<em>H</em>-(1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.

Keywords

• click chemistry
• 1,2,3-triazoles
• &lt;em&gt;Candida &lt;/em&gt;spp.
• antifungal activity