The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments

Alane N. Bezerra; Alane N. Bezerra; Caroline L. Peixoto; Synara C. Lopes; Veralice M. S. Bruin; Pedro Felipe C. Bruin; Reinaldo B. Oriá

doi:10.3389/fnut.2023.1217173

Frontiers in Nutrition (Nov 2023)

The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments

Alane N. Bezerra,
Alane N. Bezerra,
Caroline L. Peixoto,
Synara C. Lopes,
Veralice M. S. Bruin,
Pedro Felipe C. Bruin,
Reinaldo B. Oriá

Affiliations

Alane N. Bezerra: Laboratory of Tissue Healing, Ontogeny, and Nutrition, Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Alane N. Bezerra: Laboratory of Sleep and Biological Rhythms, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Caroline L. Peixoto: Laboratory of Tissue Healing, Ontogeny, and Nutrition, Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Synara C. Lopes: Laboratory of Tissue Healing, Ontogeny, and Nutrition, Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Veralice M. S. Bruin: Laboratory of Sleep and Biological Rhythms, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Pedro Felipe C. Bruin: Laboratory of Sleep and Biological Rhythms, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil
Reinaldo B. Oriá: Laboratory of Tissue Healing, Ontogeny, and Nutrition, Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortalez, Brazil

DOI: https://doi.org/10.3389/fnut.2023.1217173
Journal volume & issue: Vol. 10

Abstract

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Graphical AbstractPoor environmental conditions combined with continuous unhealthy and unsafe diets may substantially increase the risk of a vicious cycle of enteric infections (EED–environmental enteric dysfunction) and malnutrition (DBM–double burden of malnutrition) in children. Gut melatonin, mainly produced by the intestinal microbiota, can modulate the composition, variety, and dynamics of the microbiota itself and may affect and be affected by intestinal microbiota alterations due to DBM and EED.

Published in Frontiers in Nutrition

ISSN: 2296-861X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.frontiersin.org/journals/nutrition/

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Abstract

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