Synthesis of two PNA thymine monomers based on L-alanine and glycine

Abstract

Effective preparative synthesis of two thymine containing monomers of polyamide DNA-mimics based on L-alanine and glycine is presented. The results of investigation are more effective steps for allyl ester protective group incorporation and coupling of thymin-1-yl acetic acid with pseudopeptide intermediate.

Keywords

• peptide nucleic acids (pna)
• chiral monomers of pna
• pseudopeptides
• mitsunobu reaction