Nature Communications (Jul 2020)
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
- Noura Alzahofi,
- Tobias Welz,
- Christopher L. Robinson,
- Emma L. Page,
- Deborah A. Briggs,
- Amy K. Stainthorp,
- James Reekes,
- David A. Elbe,
- Felix Straub,
- Wouter W. Kallemeijn,
- Edward W. Tate,
- Philip S. Goff,
- Elena V. Sviderskaya,
- Marta Cantero,
- Lluis Montoliu,
- Francois Nedelec,
- Amanda K. Miles,
- Maryse Bailly,
- Eugen Kerkhoff,
- Alistair N. Hume
Affiliations
- Noura Alzahofi
- School of Life Sciences, University of Nottingham
- Tobias Welz
- University Hospital Regensburg
- Christopher L. Robinson
- School of Life Sciences, University of Nottingham
- Emma L. Page
- School of Life Sciences, University of Nottingham
- Deborah A. Briggs
- School of Life Sciences, University of Nottingham
- Amy K. Stainthorp
- School of Life Sciences, University of Nottingham
- James Reekes
- School of Life Sciences, University of Nottingham
- David A. Elbe
- School of Life Sciences, University of Nottingham
- Felix Straub
- University Hospital Regensburg
- Wouter W. Kallemeijn
- Department of Chemistry, Imperial College London, Molecular Sciences Research Hub
- Edward W. Tate
- Department of Chemistry, Imperial College London, Molecular Sciences Research Hub
- Philip S. Goff
- Cell Biology and Genetics Research Centre, St. George’s, University of London
- Elena V. Sviderskaya
- Cell Biology and Genetics Research Centre, St. George’s, University of London
- Marta Cantero
- Centro Nacional de Biotecnologia (CNB-CSIC)
- Lluis Montoliu
- Centro Nacional de Biotecnologia (CNB-CSIC)
- Francois Nedelec
- Sainsbury Laboratory, Cambridge University
- Amanda K. Miles
- John van Geest Cancer Research Centre, Nottingham Trent University
- Maryse Bailly
- UCL Institute of Ophthalmology
- Eugen Kerkhoff
- University Hospital Regensburg
- Alistair N. Hume
- School of Life Sciences, University of Nottingham
- DOI
- https://doi.org/10.1038/s41467-020-17212-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.
