MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

Jeongeun Hyun; Sihyung Wang; Jieun Kim; Kummara Madhusudana Rao; Soo Yong Park; Ildoo Chung; Chang-Sik Ha; Sang-Woo Kim; Yang H. Yun; Youngmi Jung

doi:10.1038/ncomms10993

Nature Communications (Mar 2016)

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

Jeongeun Hyun,
Sihyung Wang,
Jieun Kim,
Kummara Madhusudana Rao,
Soo Yong Park,
Ildoo Chung,
Chang-Sik Ha,
Sang-Woo Kim,
Yang H. Yun,
Youngmi Jung

Affiliations

Jeongeun Hyun: Department of Integrated Biological Science, College of Natural Science, Pusan National University
Sihyung Wang: Department of Integrated Biological Science, College of Natural Science, Pusan National University
Jieun Kim: Department of Integrated Biological Science, College of Natural Science, Pusan National University
Kummara Madhusudana Rao: Department of Polymer Science and Engineering, College of Engineering, Pusan National University
Soo Yong Park: Department of Polymer Science and Engineering, College of Engineering, Pusan National University
Ildoo Chung: Department of Polymer Science and Engineering, College of Engineering, Pusan National University
Chang-Sik Ha: Department of Polymer Science and Engineering, College of Engineering, Pusan National University
Sang-Woo Kim: Department of Integrated Biological Science, College of Natural Science, Pusan National University
Yang H. Yun: Department of Biomedical Engineering, College of Engineering, The University of Akron
Youngmi Jung: Department of Integrated Biological Science, College of Natural Science, Pusan National University

DOI: https://doi.org/10.1038/ncomms10993
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stellate cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal