Frontiers in Pediatrics (Mar 2022)
SARS-CoV-2 Positivity in Early Infancy: A National Cohort From Saudi Arabia
- Lana A. Shaiba,
- Lana A. Shaiba,
- Adnan Hadid,
- Adnan Hadid,
- Khalid Altirkawi,
- Khalid Altirkawi,
- Mahdi A. Alnamnakani,
- Mahdi A. Alnamnakani,
- Abdulaziz A. Almutayliq,
- Abdulaziz A. Almutayliq,
- Areen T. Alharbi,
- Areen T. Alharbi,
- Asmar M. Hijazi,
- Asmar M. Hijazi,
- Khalid M. AlMoosa,
- Khalid M. AlMoosa,
- Nora F. AlSaud,
- Nora F. AlSaud,
- Rozan E. Murshid,
- Rozan E. Murshid,
- Wejdan S. AlMuhanna,
- Wejdan S. AlMuhanna,
- Nasser A. Aldawsari,
- Maryam F. Bin Hadyan,
- Rana Almaghrabi,
- Yousef M. Alsofayan,
- Ahmed A. Alahmari,
- Yasir S. Almuzaini,
- Fahad A. Alamri,
- Anas A. Khan,
- Anas A. Khan,
- Prakesh S. Shah,
- Prakesh S. Shah,
- Prakesh S. Shah
Affiliations
- Lana A. Shaiba
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Lana A. Shaiba
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Adnan Hadid
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Adnan Hadid
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Khalid Altirkawi
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Khalid Altirkawi
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Mahdi A. Alnamnakani
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Mahdi A. Alnamnakani
- Department of Pediatrics, King Saud University Medical City, Riyadh, Saudi Arabia
- Abdulaziz A. Almutayliq
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Abdulaziz A. Almutayliq
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Areen T. Alharbi
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Areen T. Alharbi
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Asmar M. Hijazi
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Asmar M. Hijazi
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Khalid M. AlMoosa
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Khalid M. AlMoosa
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Nora F. AlSaud
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Nora F. AlSaud
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Rozan E. Murshid
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Rozan E. Murshid
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Wejdan S. AlMuhanna
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Wejdan S. AlMuhanna
- Department of Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia
- Nasser A. Aldawsari
- Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Maryam F. Bin Hadyan
- Department of Pediatrics, King Fahad Medical City, Riyadh, Saudi Arabia
- Rana Almaghrabi
- Department of Pediatrics, Pediatric Infectious Disease, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
- Yousef M. Alsofayan
- Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia
- Ahmed A. Alahmari
- Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia
- Yasir S. Almuzaini
- Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia
- Fahad A. Alamri
- Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia
- Anas A. Khan
- Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia
- Anas A. Khan
- Department of Emergency Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
- Prakesh S. Shah
- Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada
- Prakesh S. Shah
- Department of Pediatrics, Toronto University, Toronto, ON, Canada
- Prakesh S. Shah
- 0Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada
- DOI
- https://doi.org/10.3389/fped.2022.849659
- Journal volume & issue
-
Vol. 10
Abstract
BackgroundData on SARS-CoV-2 in infants ≤ 90 days are limited with conflicting reports regarding its presentation and outcomes.MethodsWe conducted an ambispective cohort study using prospectively collected Health Electronic Surveillance Network Database by the Ministry of Health, Saudi Arabia. Infants of ≤ 90 days of age who had a positive RT-PCR test for SARS-CoV-2 virus were included. Patients were divided in Early neonatal (0–6 days), late neonatal (7–27 days), and post- neonatal (28–90 days) groups and were compared for clinical characteristics and outcomes by contacting parents and collecting information retrospectively.ResultsOf 1,793 infants, 898 infants were included for analysis. Most infants in the early neonatal group had no features of infection (tested based on maternal positivity), whereas most infants in the late and post- neonatal groups were tested because of clinical features of infection. Fever and respiratory signs were the most common presenting feature in the late and post-neonatal groups. Hospitalization was higher in the early neonatal group (80%), compared to the two other groups. The overall mortality in the cohort was 1.6%.ConclusionSARS-CoV-2 infection in infants ≤ 90 days might not be as rare as previously reported. The clinical presentation varies based on age at positive RT-PCR result.
Keywords
