International Journal of Molecular Sciences (Jun 2018)
Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting
- Maria Elisabeth Street,
- Sabrina Angelini,
- Sergio Bernasconi,
- Ernesto Burgio,
- Alessandra Cassio,
- Cecilia Catellani,
- Francesca Cirillo,
- Annalisa Deodati,
- Enrica Fabbrizi,
- Vassilios Fanos,
- Giancarlo Gargano,
- Enzo Grossi,
- Lorenzo Iughetti,
- Pietro Lazzeroni,
- Alberto Mantovani,
- Lucia Migliore,
- Paola Palanza,
- Giancarlo Panzica,
- Anna Maria Papini,
- Stefano Parmigiani,
- Barbara Predieri,
- Chiara Sartori,
- Gabriele Tridenti,
- Sergio Amarri
Affiliations
- Maria Elisabeth Street
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Sabrina Angelini
- Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
- Sergio Bernasconi
- Former Department of Medicine, University of Parma, Via A. Catalani 10, 43123 Parma, Italy
- Ernesto Burgio
- ECERI European Cancer and Environment Research Institute, Square de Meeus, 38-40, 1000 Bruxelles, Belgium
- Alessandra Cassio
- Pediatric Endocrinology Programme, Pediatrics Unit, Department of Woman, Child Health and Urologic Diseases, AOU S. Orsola-Malpighi, Via Massarenti, 11, 40138 Bologna, Italy
- Cecilia Catellani
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Francesca Cirillo
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Annalisa Deodati
- Department of Pediatrics (DPUO), Bambino Gesù Children’s Hospital, Tor Vergata University, Piazza S. Onofrio 4, 00165 Rome, Italy
- Enrica Fabbrizi
- Department of Pediatrics and Neonatology, Augusto Murri Hospital, Via Augusto Murri, 17, 63900 Fermo, Itlay
- Vassilios Fanos
- Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, AOU and University of Cagliari, via Ospedale, 54, 09124 Cagliari, Italy
- Giancarlo Gargano
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Enzo Grossi
- Villa Santa Maria Institute, Neuropsychiatric Rehabilitation Center, Via IV Novembre 15, 22038 Tavernerio (Como), Italy
- Lorenzo Iughetti
- Department of Medical and Surgical Sciences of the Mother, Children and Adults, Pediatrics Unit, University of Modena and Reggio Emilia, via del Pozzo, 71, 41124 Modena, Italy
- Pietro Lazzeroni
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Alberto Mantovani
- Department of Veterinary Public Health and Food Safety, Food and Veterinary Toxicology Unit ISS–National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
- Lucia Migliore
- Department of Traslational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 55, 56123 Pisa, Italy
- Paola Palanza
- Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Via Gramsci, 14, 43126 Parma, Italy
- Giancarlo Panzica
- Laboratory of Neuroendocrinology, Department of Neuroscience Rita Levi Montalcini, University of Turin, Via Cherasco 15, 10126 Turin, Italy
- Anna Maria Papini
- Department of Chemistry ‘Ugo Schiff’, University of Florence, Via della Lastruccia, 3-13, 50019 Sesto Fiorentino, Florence, Italy
- Stefano Parmigiani
- Unit of Evolutionary and Functional Biology—Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA)-University of Parma–11/a, 43124 Parma, Italy
- Barbara Predieri
- Department of Medical and Surgical Sciences of the Mother, Children and Adults, Pediatrics Unit, University of Modena and Reggio Emilia, via del Pozzo, 71, 41124 Modena, Italy
- Chiara Sartori
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Gabriele Tridenti
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- Sergio Amarri
- Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
- DOI
- https://doi.org/10.3390/ijms19061647
- Journal volume & issue
-
Vol. 19,
no. 6
p. 1647
Abstract
Wildlife has often presented and suggested the effects of endocrine disrupting chemicals (EDCs). Animal studies have given us an important opportunity to understand the mechanisms of action of many chemicals on the endocrine system and on neurodevelopment and behaviour, and to evaluate the effects of doses, time and duration of exposure. Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. This manuscript reviews the reports of a multidisciplinary national meeting on this topic.
Keywords
- Endocrine Disrupting Chemicals (EDCs)
- neurodevelopment
- autism
- obesity
- puberty
- fertility
- thyroid function
- epigenetics
- carcinogenesis
- growth
