Nature Communications (Oct 2018)
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia
- Mary L. McMaster,
- Sonja I. Berndt,
- Jianqing Zhang,
- Susan L. Slager,
- Shengchao Alfred Li,
- Claire M. Vajdic,
- Karin E. Smedby,
- Huihuang Yan,
- Brenda M. Birmann,
- Elizabeth E. Brown,
- Alex Smith,
- Geffen Kleinstern,
- Mervin M. Fansler,
- Christine Mayr,
- Bin Zhu,
- Charles C. Chung,
- Ju-Hyun Park,
- Laurie Burdette,
- Belynda D. Hicks,
- Amy Hutchinson,
- Lauren R. Teras,
- Hans-Olov Adami,
- Paige M. Bracci,
- James McKay,
- Alain Monnereau,
- Brian K. Link,
- Roel C. H. Vermeulen,
- Stephen M. Ansell,
- Ann Maria,
- W. Ryan Diver,
- Mads Melbye,
- Akinyemi I. Ojesina,
- Peter Kraft,
- Paolo Boffetta,
- Jacqueline Clavel,
- Edward Giovannucci,
- Caroline M. Besson,
- Federico Canzian,
- Ruth C. Travis,
- Paolo Vineis,
- Elisabete Weiderpass,
- Rebecca Montalvan,
- Zhaoming Wang,
- Meredith Yeager,
- Nikolaus Becker,
- Yolanda Benavente,
- Paul Brennan,
- Lenka Foretova,
- Marc Maynadie,
- Alexandra Nieters,
- Silvia de Sanjose,
- Anthony Staines,
- Lucia Conde,
- Jacques Riby,
- Bengt Glimelius,
- Henrik Hjalgrim,
- Nisha Pradhan,
- Andrew L. Feldman,
- Anne J. Novak,
- Charles Lawrence,
- Bryan A. Bassig,
- Qing Lan,
- Tongzhang Zheng,
- Kari E. North,
- Lesley F. Tinker,
- Wendy Cozen,
- Richard K. Severson,
- Jonathan N. Hofmann,
- Yawei Zhang,
- Rebecca D. Jackson,
- Lindsay M. Morton,
- Mark P. Purdue,
- Nilanjan Chatterjee,
- Kenneth Offit,
- James R. Cerhan,
- Stephen J. Chanock,
- Nathaniel Rothman,
- Joseph Vijai,
- Lynn R. Goldin,
- Christine F. Skibola,
- Neil E. Caporaso
Affiliations
- Mary L. McMaster
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jianqing Zhang
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Susan L. Slager
- Department of Health Sciences Research, Mayo Clinic
- Shengchao Alfred Li
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Claire M. Vajdic
- Centre for Big Data Research in Health, University of New South Wales
- Karin E. Smedby
- Department of Medicine, Solna Karolinska Institutet
- Huihuang Yan
- Department of Health Sciences Research, Mayo Clinic
- Brenda M. Birmann
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Elizabeth E. Brown
- Department of Pathology, University of Alabama at Birmingham
- Alex Smith
- Department of Health Sciences, University of York
- Geffen Kleinstern
- Department of Health Sciences Research, Mayo Clinic
- Mervin M. Fansler
- Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Graduate College
- Christine Mayr
- Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
- Bin Zhu
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Charles C. Chung
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Ju-Hyun Park
- Department of Statistics, Dongguk University
- Laurie Burdette
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Belynda D. Hicks
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Amy Hutchinson
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Lauren R. Teras
- Epidemiology Research Program, American Cancer Society
- Hans-Olov Adami
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Paige M. Bracci
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- James McKay
- International Agency for Research on Cancer (IARC)
- Alain Monnereau
- Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
- Brian K. Link
- Department of Internal Medicine, Carver College of Medicine, The University of Iowa
- Roel C. H. Vermeulen
- Institute for Risk Assessment Sciences, Utrecht University
- Stephen M. Ansell
- Department of Internal Medicine, Mayo Clinic
- Ann Maria
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- W. Ryan Diver
- Epidemiology Research Program, American Cancer Society
- Mads Melbye
- Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut
- Akinyemi I. Ojesina
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Paolo Boffetta
- The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Jacqueline Clavel
- Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
- Edward Giovannucci
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Caroline M. Besson
- Service d’hématologie et Oncologie, Centre Hospitalier de Versailles, Le Chesnay, Inserm U1018, Centre pour la Recherche en Epidémiologie et Santé des Populations (CESP)
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Ruth C. Travis
- Cancer Epidemiology Unit, University of Oxford
- Paolo Vineis
- MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Elisabete Weiderpass
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Rebecca Montalvan
- Westat
- Zhaoming Wang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Meredith Yeager
- Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
- Nikolaus Becker
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Yolanda Benavente
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- Paul Brennan
- International Agency for Research on Cancer (IARC)
- Lenka Foretova
- Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU
- Marc Maynadie
- EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital
- Alexandra Nieters
- Center for Chronic Immunodeficiency, University Medical Center Freiburg
- Silvia de Sanjose
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- Anthony Staines
- School of Nursing and Human Sciences, Dublin City University
- Lucia Conde
- Bill Lyons Informatics Centre, UCL Cancer Institute, University College London
- Jacques Riby
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Bengt Glimelius
- Department of Immunology, Genetics and Pathology, Uppsala University
- Henrik Hjalgrim
- Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut
- Nisha Pradhan
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Andrew L. Feldman
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Anne J. Novak
- Department of Internal Medicine, Mayo Clinic
- Charles Lawrence
- Westat
- Bryan A. Bassig
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Qing Lan
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Tongzhang Zheng
- Department of Epidemiology, Brown University
- Kari E. North
- Department of Epidemiology, University of North Carolina at Chapel Hill
- Lesley F. Tinker
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Wendy Cozen
- Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California
- Richard K. Severson
- Department of Family Medicine and Public Health Sciences, Wayne State University
- Jonathan N. Hofmann
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Yawei Zhang
- Department of Environmental Health Sciences, Yale School of Public Health
- Rebecca D. Jackson
- Division of Endocrinology, Diabetes and Metabolism, The Ohio State University
- Lindsay M. Morton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Mark P. Purdue
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nilanjan Chatterjee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kenneth Offit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- James R. Cerhan
- Department of Health Sciences Research, Mayo Clinic
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Joseph Vijai
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Lynn R. Goldin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Christine F. Skibola
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Neil E. Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-018-06541-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a non-Hodgkin-type B cell lymphoma. Here, the authors identify two risk loci for WM/LPL in a two-stage GWAS involving a family-oversampling approach and provide evidence for a functional role of the non-coding SNP rs116446171.
