Validation of Whole Blood Rapid Diagnosis Test for Hepatitis B

Jose D. Debes; Gertine van Oord; Andre Boonstra

doi:10.5334/aogh.2866

Annals of Global Health (May 2020)

Validation of Whole Blood Rapid Diagnosis Test for Hepatitis B

Jose D. Debes,
Gertine van Oord,
Andre Boonstra

Affiliations

Jose D. Debes: Department of Medicine, University of Minnesota, Minneapolis, MN, US; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam
Gertine van Oord: Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam
Andre Boonstra: Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam

DOI: https://doi.org/10.5334/aogh.2866
Journal volume & issue: Vol. 86, no. 1

Abstract

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We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all genotypes other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensitivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.

Published in Annals of Global Health

ISSN: 2214-9996 (Online)
Publisher: Ubiquity Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.annalsofglobalhealth.org/

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