H2A.Z deposition by SWR1C involves multiple ATP-dependent steps

Jiayi Fan; Andrew T. Moreno; Alexander S. Baier; Joseph J. Loparo; Craig L. Peterson

doi:10.1038/s41467-022-34861-x

Nature Communications (Nov 2022)

H2A.Z deposition by SWR1C involves multiple ATP-dependent steps

Jiayi Fan,
Andrew T. Moreno,
Alexander S. Baier,
Joseph J. Loparo,
Craig L. Peterson

Affiliations

Jiayi Fan: Program in Molecular Medicine, University of Massachusetts Chan Medical School
Andrew T. Moreno: Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School
Alexander S. Baier: Program in Molecular Medicine, University of Massachusetts Chan Medical School
Joseph J. Loparo: Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School
Craig L. Peterson: Program in Molecular Medicine, University of Massachusetts Chan Medical School

DOI: https://doi.org/10.1038/s41467-022-34861-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The multi-subunit SWR1C remodeler deposits histone variant H2A.Z at nucleosomes flanking protein-coding genes. Here the authors use single-molecule and ensemble methodologies to identify three ATP-dependent phases in the H2A.Z deposition reaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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