Association between changes in bodyweight and cardiovascular disease risk factors among obese Japanese patients with type 2 diabetes

Abstract

Abstract Aims/Introduction We aimed to assess the association between bodyweight reduction and cardiovascular disease risk factors, and to identify the minimum bodyweight reduction associated with significant improvement in cardiovascular disease risk factors among obese Japanese patients with type 2 diabetes. Materials and Methods The cohort comprised 1,753 patients with type 2 diabetes and body mass index ≥25 kg/m2, who visited our clinic between 2013 and 2016. Multivariable linear regression analysis was carried out to assess the relationship between bodyweight changes and glycated hemoglobin A1c, serum lipids and blood pressure. Analyses of covariance were carried out to compare mean changes in cardiovascular disease risk factors across six groups of bodyweight change, 5% bodyweight reduction was associated with improved glycated hemoglobin A1c.

Keywords

• Bodyweight reduction
• Cardiovascular disease risk factors
• Type 2 diabetes