Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

Martin Stražar; Godfrey S. Temba; Hera Vlamakis; Vesla I. Kullaya; Furaha Lyamuya; Blandina T. Mmbaga; Leo A. B. Joosten; Andre J. A. M. van der Ven; Mihai G. Netea; Quirijn de Mast; Ramnik J. Xavier

doi:10.1038/s41467-021-25213-2

Nature Communications (Aug 2021)

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

Martin Stražar,
Godfrey S. Temba,
Hera Vlamakis,
Vesla I. Kullaya,
Furaha Lyamuya,
Blandina T. Mmbaga,
Leo A. B. Joosten,
Andre J. A. M. van der Ven,
Mihai G. Netea,
Quirijn de Mast,
Ramnik J. Xavier

Affiliations

Martin Stražar: Broad Institute of MIT and Harvard
Godfrey S. Temba: Kilimanjaro Christian Medical University College
Hera Vlamakis: Broad Institute of MIT and Harvard
Vesla I. Kullaya: Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre
Furaha Lyamuya: Kilimanjaro Christian Medical University College
Blandina T. Mmbaga: Department of Pediatrics, Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre
Leo A. B. Joosten: Department of Internal Medicine, Radboud University Medical Center
Andre J. A. M. van der Ven: Department of Internal Medicine, Radboud University Medical Center
Mihai G. Netea: Department of Internal Medicine, Radboud University Medical Center
Quirijn de Mast: Department of Internal Medicine, Radboud University Medical Center
Ramnik J. Xavier: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-021-25213-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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