Surface chemistry governs cellular tropism of nanoparticles in the brain

Eric Song; Alice Gaudin; Amanda R. King; Young-Eun Seo; Hee-Won Suh; Yang Deng; Jiajia Cui; Gregory T. Tietjen; Anita Huttner; W. Mark Saltzman

doi:10.1038/ncomms15322

Nature Communications (May 2017)

Surface chemistry governs cellular tropism of nanoparticles in the brain

Eric Song,
Alice Gaudin,
Amanda R. King,
Young-Eun Seo,
Hee-Won Suh,
Yang Deng,
Jiajia Cui,
Gregory T. Tietjen,
Anita Huttner,
W. Mark Saltzman

Affiliations

Eric Song: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Alice Gaudin: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Amanda R. King: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Young-Eun Seo: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Hee-Won Suh: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Yang Deng: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Jiajia Cui: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Gregory T. Tietjen: Department of Biomedical Engineering, Malone Engineering Center, Yale University
Anita Huttner: Department of Pathology, Yale University
W. Mark Saltzman: Department of Biomedical Engineering, Malone Engineering Center, Yale University

DOI: https://doi.org/10.1038/ncomms15322
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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There have been numerous attempts to develop nanomaterials to reach cells of the central nervous system for drug delivery. Here, the authors investigate the cellular fate of polymer-based nanoparticles with varying surface chemistries after administration directly into the brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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