Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters

Abstract

Cancer has become one of the most significant health challenges for both human and veterinary medicine. The present study examined the antineoplastic and antimetastatic activity of the novel membrane-targeting anticancer agent erufosine. The antitumour effects of erufosine on Graffi virus-induced experimental myeloid tumour in hamsters was assessed by histopathological methods and evaluation of some biometric parameters of tumour growth. Two schemes of experimental antitumour therapy were applied  one that started simultaneously with the tumour transplantation and a second one that started after the appearance of palpable tumours. The results demonstrated protective antitu-mour effect of erufosine, expressed by decrease of transplantability, tumour growth inhibition, sup-pression of metastatic activity and extension of mean survival time. The effectivity of the experimental therapy was more pronounced when it was started simultaneously with the transplantation of the tumour cells. Presented results suggest that erufosine is a promising drug candidate for treatment of haematological malignances.

Keywords

• alkylphosphocholines
• antitumour activity
• erufosine
• myeloid tumour