Nature Communications (Feb 2016)

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

  • Krista Dubin,
  • Margaret K. Callahan,
  • Boyu Ren,
  • Raya Khanin,
  • Agnes Viale,
  • Lilan Ling,
  • Daniel No,
  • Asia Gobourne,
  • Eric Littmann,
  • Curtis Huttenhower,
  • Eric G. Pamer,
  • Jedd D. Wolchok

DOI
https://doi.org/10.1038/ncomms10391
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment.