Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Qin Qin Huang; Howard H. F. Tang; Shu Mei Teo; Danny Mok; Scott C. Ritchie; Artika P. Nath; Marta Brozynska; Agus Salim; Andrew Bakshi; Barbara J. Holt; Chiea Chuen Khor; Peter D. Sly; Patrick G. Holt; Kathryn E. Holt; Michael Inouye

doi:10.1038/s41467-020-17477-x

Nature Communications (Jul 2020)

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Qin Qin Huang,
Howard H. F. Tang,
Shu Mei Teo,
Danny Mok,
Scott C. Ritchie,
Artika P. Nath,
Marta Brozynska,
Agus Salim,
Andrew Bakshi,
Barbara J. Holt,
Chiea Chuen Khor,
Peter D. Sly,
Patrick G. Holt,
Kathryn E. Holt,
Michael Inouye

Affiliations

Qin Qin Huang: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Howard H. F. Tang: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Shu Mei Teo: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Danny Mok: Telethon Kids Institute, The University of Western Australia
Scott C. Ritchie: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Artika P. Nath: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Marta Brozynska: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute
Agus Salim: Baker Heart and Diabetes Institute
Andrew Bakshi: Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University
Barbara J. Holt: Telethon Kids Institute, The University of Western Australia
Chiea Chuen Khor: Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
Peter D. Sly: Child Health Research Centre, The University of Queensland
Patrick G. Holt: Telethon Kids Institute, The University of Western Australia
Kathryn E. Holt: Department of Infectious Diseases, Central Clinical School, Monash University
Michael Inouye: Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute

DOI: https://doi.org/10.1038/s41467-020-17477-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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