Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro

Ting Tian; Ting Tian; Ting Tian; Weihan Xie; Weihan Xie; Weihan Xie; Wendong Gao; Wendong Gao; Wendong Gao; Gang Wang; Gang Wang; Gang Wang; Lei Zeng; Lei Zeng; Lei Zeng; Guohou Miao; Bo Lei; Zhanyi Lin; Zhanyi Lin; Xiaofeng Chen; Xiaofeng Chen; Xiaofeng Chen

doi:10.3389/fchem.2019.00186

Frontiers in Chemistry (Mar 2019)

Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro

Ting Tian,
Ting Tian,
Ting Tian,
Weihan Xie,
Weihan Xie,
Weihan Xie,
Wendong Gao,
Wendong Gao,
Wendong Gao,
Gang Wang,
Gang Wang,
Gang Wang,
Lei Zeng,
Lei Zeng,
Lei Zeng,
Guohou Miao,
Bo Lei,
Zhanyi Lin,
Zhanyi Lin,
Xiaofeng Chen,
Xiaofeng Chen,
Xiaofeng Chen

Affiliations

Ting Tian: Guangzhou Higher Education Mega Center, School of Medicine, South China University of Technology, Guangzhou, China
Ting Tian: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Ting Tian: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Weihan Xie: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Weihan Xie: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Weihan Xie: Key Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, China
Wendong Gao: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Wendong Gao: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Wendong Gao: Key Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, China
Gang Wang: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Gang Wang: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Gang Wang: Key Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, China
Lei Zeng: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Lei Zeng: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Lei Zeng: Key Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, China
Guohou Miao: Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China
Bo Lei: Instrument Analysis Center, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China
Zhanyi Lin: Guangzhou Higher Education Mega Center, School of Medicine, South China University of Technology, Guangzhou, China
Zhanyi Lin: Department of Cardiology, Guangdong General Hospital, School of Medicine, South China University of Technology, Guangdong, China
Xiaofeng Chen: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Xiaofeng Chen: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China
Xiaofeng Chen: Key Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, China

DOI: https://doi.org/10.3389/fchem.2019.00186
Journal volume & issue: Vol. 7

Abstract

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Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The in vitro studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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