New acylides: synthesis of 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives

Deepa Pandey; Wahajul Haq; Seturam B. Katti

doi:10.3762/bjoc.4.14

Beilstein Journal of Organic Chemistry (May 2008)

New acylides: synthesis of 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives

Deepa Pandey,
Wahajul Haq,
Seturam B. Katti

Affiliations

Deepa Pandey: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001 India. Telephone: +91 0522 2612411-18 ext. 4364; fax: +91 0522 2623405
Wahajul Haq: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001 India. Telephone: +91 0522 2612411-18 ext. 4364; fax: +91 0522 2623405
Seturam B. Katti: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001 India. Telephone: +91 0522 2612411-18 ext. 4364; fax: +91 0522 2623405

DOI: https://doi.org/10.3762/bjoc.4.14
Journal volume & issue: Vol. 4, no. 1
p. 14

Abstract

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In search of new erythromycin derivatives 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives have been synthesized. The 3-hydroxy group was derivatised to a primary amine and subsequently the thiazolidinone nucleus was generated at the amino functionality through DCC mediated one-pot three-component reaction in good yields.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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