Calcium sensing by the STIM1 ER-luminal domain

Aparna Gudlur; Ana Eliza Zeraik; Nupura Hirve; V. Rajanikanth; Andrey A. Bobkov; Guolin Ma; Sisi Zheng; Youjun Wang; Yubin Zhou; Elizabeth A. Komives; Patrick G. Hogan

doi:10.1038/s41467-018-06816-8

Nature Communications (Oct 2018)

Calcium sensing by the STIM1 ER-luminal domain

Aparna Gudlur,
Ana Eliza Zeraik,
Nupura Hirve,
V. Rajanikanth,
Andrey A. Bobkov,
Guolin Ma,
Sisi Zheng,
Youjun Wang,
Yubin Zhou,
Elizabeth A. Komives,
Patrick G. Hogan

Affiliations

Aparna Gudlur: Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology
Ana Eliza Zeraik: Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology
Nupura Hirve: Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology
V. Rajanikanth: Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology
Andrey A. Bobkov: Protein Production and Analysis Facility, Sanford Burnham Prebys Medical Discovery Institute
Guolin Ma: Center for Translational Cancer Research, Institute of Biosciences & Technology, College of Medicine, Texas A&M University
Sisi Zheng: Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University
Youjun Wang: Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University
Yubin Zhou: Center for Translational Cancer Research, Institute of Biosciences & Technology, College of Medicine, Texas A&M University
Elizabeth A. Komives: Department of Chemistry and Biochemistry, University of California–San Diego
Patrick G. Hogan: Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology

DOI: https://doi.org/10.1038/s41467-018-06816-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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