Nature Communications (Mar 2017)
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
- Shuo Xiao,
- Jonathan R. Coppeta,
- Hunter B. Rogers,
- Brett C. Isenberg,
- Jie Zhu,
- Susan A. Olalekan,
- Kelly E. McKinnon,
- Danijela Dokic,
- Alexandra S. Rashedi,
- Daniel J. Haisenleder,
- Saurabh S. Malpani,
- Chanel A. Arnold-Murray,
- Kuanwei Chen,
- Mingyang Jiang,
- Lu Bai,
- Catherine T. Nguyen,
- Jiyang Zhang,
- Monica M. Laronda,
- Thomas J. Hope,
- Kruti P. Maniar,
- Mary Ellen Pavone,
- Michael J. Avram,
- Elizabeth C. Sefton,
- Spiro Getsios,
- Joanna E. Burdette,
- J. Julie Kim,
- Jeffrey T. Borenstein,
- Teresa K. Woodruff
Affiliations
- Shuo Xiao
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Jonathan R. Coppeta
- The Charles Stark Draper Laboratory
- Hunter B. Rogers
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Brett C. Isenberg
- The Charles Stark Draper Laboratory
- Jie Zhu
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Susan A. Olalekan
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Kelly E. McKinnon
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Danijela Dokic
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Alexandra S. Rashedi
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Daniel J. Haisenleder
- Ligand Assay and Analysis Core, Center for Research in Reproduction, University of Virginia
- Saurabh S. Malpani
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Chanel A. Arnold-Murray
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Kuanwei Chen
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Mingyang Jiang
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Lu Bai
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Catherine T. Nguyen
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Jiyang Zhang
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Monica M. Laronda
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Thomas J. Hope
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Kruti P. Maniar
- Department of Pathology, Feinberg School of Medicine, Northwestern University
- Mary Ellen Pavone
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Michael J. Avram
- Department of Anesthesiology, Feinberg School of Medicine, Northwestern University
- Elizabeth C. Sefton
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Spiro Getsios
- Department of Dermatology, Feinberg School of Medicine, Northwestern University
- Joanna E. Burdette
- Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago
- J. Julie Kim
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- Jeffrey T. Borenstein
- The Charles Stark Draper Laboratory
- Teresa K. Woodruff
- Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University
- DOI
- https://doi.org/10.1038/ncomms14584
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The female reproductive tract constitutes the ovary, fallopian tubes, uterus, and cervix, but it is challenging to engineer this systemin vitro. Here, the authors develop a microfluidic device (EVATAR) with reproductive tract and peripheral tissues to replicate hormone release of a 28-day menstrual cycle.
