Nature Communications (May 2019)

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

  • Marija Zaric,
  • Pablo D. Becker,
  • Catherine Hervouet,
  • Petya Kalcheva,
  • Andor Doszpoly,
  • Negin Blattman,
  • Lauren A. O’ Neill,
  • Barbara Ibarzo Yus,
  • Clement Cocita,
  • Sung-Yun Kwon,
  • Andrew H. Baker,
  • Graham M. Lord,
  • Linda S. Klavinskis

DOI
https://doi.org/10.1038/s41467-019-09969-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.