CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

Mable Lam; Koji Takeo; Rafael G. Almeida; Madeline H. Cooper; Kathryn Wu; Manasi Iyer; Husniye Kantarci; J. Bradley Zuchero

doi:10.1038/s41467-022-33200-4

Nature Communications (Sep 2022)

CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

Mable Lam,
Koji Takeo,
Rafael G. Almeida,
Madeline H. Cooper,
Kathryn Wu,
Manasi Iyer,
Husniye Kantarci,
J. Bradley Zuchero

Affiliations

Mable Lam: Department of Neurosurgery, Stanford University School of Medicine
Koji Takeo: Department of Neurosurgery, Stanford University School of Medicine
Rafael G. Almeida: Centre for Discovery Brain Sciences, University of Edinburgh
Madeline H. Cooper: Department of Neurosurgery, Stanford University School of Medicine
Kathryn Wu: Department of Neurosurgery, Stanford University School of Medicine
Manasi Iyer: Department of Neurosurgery, Stanford University School of Medicine
Husniye Kantarci: Department of Neurosurgery, Stanford University School of Medicine
J. Bradley Zuchero: Department of Neurosurgery, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-33200-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Understanding myelination is important for CNS plasticity and disease. Here the authors show exocytosis mediated by the vesicular SNARE proteins VAMP2/3 is involved in oligodendrocyte membrane expansion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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