OncoImmunology (Dec 2023)
Cell type-specific induction of ferroptosis to boost antitumor immunity
Abstract
ABSTRACTTraditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.
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