Communications Biology (Oct 2022)
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
- Sean M. Gross,
- Mark A. Dane,
- Rebecca L. Smith,
- Kaylyn L. Devlin,
- Ian C. McLean,
- Daniel S. Derrick,
- Caitlin E. Mills,
- Kartik Subramanian,
- Alexandra B. London,
- Denis Torre,
- John Erol Evangelista,
- Daniel J. B. Clarke,
- Zhuorui Xie,
- Cemal Erdem,
- Nicholas Lyons,
- Ted Natoli,
- Sarah Pessa,
- Xiaodong Lu,
- James Mullahoo,
- Jonathan Li,
- Miriam Adam,
- Brook Wassie,
- Moqing Liu,
- David F. Kilburn,
- Tiera A. Liby,
- Elmar Bucher,
- Crystal Sanchez-Aguila,
- Kenneth Daily,
- Larsson Omberg,
- Yunguan Wang,
- Connor Jacobson,
- Clarence Yapp,
- Mirra Chung,
- Dusica Vidovic,
- Yiling Lu,
- Stephan Schurer,
- Albert Lee,
- Ajay Pillai,
- Aravind Subramanian,
- Malvina Papanastasiou,
- Ernest Fraenkel,
- Heidi S. Feiler,
- Gordon B. Mills,
- Jake D. Jaffe,
- Avi Ma’ayan,
- Marc R. Birtwistle,
- Peter K. Sorger,
- James E. Korkola,
- Joe W. Gray,
- Laura M. Heiser
Affiliations
- Sean M. Gross
- Department of Biomedical Engineering, OHSU
- Mark A. Dane
- Department of Biomedical Engineering, OHSU
- Rebecca L. Smith
- Department of Biomedical Engineering, OHSU
- Kaylyn L. Devlin
- Department of Biomedical Engineering, OHSU
- Ian C. McLean
- Department of Biomedical Engineering, OHSU
- Daniel S. Derrick
- Department of Biomedical Engineering, OHSU
- Caitlin E. Mills
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Kartik Subramanian
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Alexandra B. London
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- Denis Torre
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- John Erol Evangelista
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- Daniel J. B. Clarke
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- Zhuorui Xie
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- Cemal Erdem
- Department of Chemical and Biomolecular Engineering, Clemson University
- Nicholas Lyons
- Broad Institute of MIT and Harvard
- Ted Natoli
- Broad Institute of MIT and Harvard
- Sarah Pessa
- Broad Institute of MIT and Harvard
- Xiaodong Lu
- Broad Institute of MIT and Harvard
- James Mullahoo
- Broad Institute of MIT and Harvard
- Jonathan Li
- Department of Biological Engineering, Massachusetts Institute of Technology
- Miriam Adam
- Department of Biological Engineering, Massachusetts Institute of Technology
- Brook Wassie
- Department of Biological Engineering, Massachusetts Institute of Technology
- Moqing Liu
- Department of Biomedical Engineering, OHSU
- David F. Kilburn
- Department of Biomedical Engineering, OHSU
- Tiera A. Liby
- Department of Biomedical Engineering, OHSU
- Elmar Bucher
- Department of Biomedical Engineering, OHSU
- Crystal Sanchez-Aguila
- Department of Biomedical Engineering, OHSU
- Kenneth Daily
- Sage Bionetworks
- Larsson Omberg
- Sage Bionetworks
- Yunguan Wang
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Connor Jacobson
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Clarence Yapp
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Mirra Chung
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- Dusica Vidovic
- Sylvester Comprehensive Cancer Center, University of Miami
- Yiling Lu
- Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
- Stephan Schurer
- Sylvester Comprehensive Cancer Center, University of Miami
- Albert Lee
- Heart, Lung, and Blood Institute, National Institutes of Health
- Ajay Pillai
- Human Genome Research Institute, National Institutes of Health
- Aravind Subramanian
- Broad Institute of MIT and Harvard
- Malvina Papanastasiou
- Broad Institute of MIT and Harvard
- Ernest Fraenkel
- Broad Institute of MIT and Harvard
- Heidi S. Feiler
- Department of Biomedical Engineering, OHSU
- Gordon B. Mills
- Knight Cancer Institute, OHSU
- Jake D. Jaffe
- Broad Institute of MIT and Harvard
- Avi Ma’ayan
- Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai
- Marc R. Birtwistle
- Department of Chemical and Biomolecular Engineering, Clemson University
- Peter K. Sorger
- Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School
- James E. Korkola
- Department of Biomedical Engineering, OHSU
- Joe W. Gray
- Department of Biomedical Engineering, OHSU
- Laura M. Heiser
- Department of Biomedical Engineering, OHSU
- DOI
- https://doi.org/10.1038/s42003-022-03975-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 20
Abstract
Comprehensive profiling of ligand-induced perturbation responses of the MCF10A mammary epithelial cell line provides an exhaustive resource for identification of the molecular basis of cellular phenotypes.
