Nature Communications (Mar 2018)
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
- Nirmesh Patel,
- Daniel Weekes,
- Konstantinos Drosopoulos,
- Patrycja Gazinska,
- Elodie Noel,
- Mamun Rashid,
- Hasan Mirza,
- Jelmar Quist,
- Fara Brasó-Maristany,
- Sumi Mathew,
- Riccardo Ferro,
- Ana Mendes Pereira,
- Cynthia Prince,
- Farzana Noor,
- Erika Francesch-Domenech,
- Rebecca Marlow,
- Emanuele de Rinaldis,
- Anita Grigoriadis,
- Spiros Linardopoulos,
- Pierfrancesco Marra,
- Andrew N. J. Tutt
Affiliations
- Nirmesh Patel
- Breast Cancer Now Research Unit, King’s College London
- Daniel Weekes
- Breast Cancer Now Research Unit, King’s College London
- Konstantinos Drosopoulos
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Patrycja Gazinska
- Breast Cancer Now Research Unit, King’s College London
- Elodie Noel
- Breast Cancer Now Research Unit, King’s College London
- Mamun Rashid
- Breast Cancer Now Research Unit, King’s College London
- Hasan Mirza
- Breast Cancer Now Research Unit, King’s College London
- Jelmar Quist
- Breast Cancer Now Research Unit, King’s College London
- Fara Brasó-Maristany
- Breast Cancer Now Research Unit, King’s College London
- Sumi Mathew
- Breast Cancer Now Research Unit, King’s College London
- Riccardo Ferro
- Breast Cancer Now Research Unit, King’s College London
- Ana Mendes Pereira
- Breast Cancer Now Research Unit, King’s College London
- Cynthia Prince
- Breast Cancer Now Research Unit, King’s College London
- Farzana Noor
- Breast Cancer Now Research Unit, King’s College London
- Erika Francesch-Domenech
- Breast Cancer Now Research Unit, King’s College London
- Rebecca Marlow
- Breast Cancer Now Research Unit, King’s College London
- Emanuele de Rinaldis
- Breast Cancer Now Research Unit, King’s College London
- Anita Grigoriadis
- Breast Cancer Now Research Unit, King’s College London
- Spiros Linardopoulos
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Pierfrancesco Marra
- Breast Cancer Now Research Unit, King’s College London
- Andrew N. J. Tutt
- Breast Cancer Now Research Unit, King’s College London
- DOI
- https://doi.org/10.1038/s41467-018-03283-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions among which they identify the mechanism of addiction to KIFC1, a potential selective drug target.
