Notum protects against myocardial infarction-induced heart dysfunction by alleviating cardiac fibrosis

Abstract

Cardiac fibrosis is a pathological reparative process that follows myocardial infarctionand is associated with compromised cardiac systolic and reduced cardiac compliance. The Wnt signaling pathway is closely implicated in organ fibrosis, and Notum, a highly conserved secreted inhibitor, modulates Wnt signaling. The objective of this study was to explore the role and mechanism of Notum in cardiac fibrosis.

Keywords

• cardiac fibrosis
• notum
• wnt/β-catenin
• senescence
• myocardial infarction