Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies

Abstract

Highlights The Ras (Rat Sarcoma) gene family is a group of small G proteins Ras is regulated by growth factors and neurohormones affecting cardiomyocyte growth and hypertrophy Ras directly affects cardiomyocyte physiological and pathological hypertrophy Genetic alterations of Ras and its pathways result in various cardiac phenotypes Ras and its pathway are differentially regulated in acquired heart disease Ras modulation is a promising therapeutic target in various cardiac conditions.

Keywords

• Ras-opathies
• H-Ras gene
• K-Ras gene
• Ras pathway
• Physiological hypertrophy
• Pathological hypertrophy