A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

Atsuko Nakatsuka; Satoshi Yamaguchi; Jun Eguchi; Shigeru Kakuta; Yoichiro Iwakura; Hitoshi Sugiyama; Jun Wada

doi:10.1038/s42003-021-01902-y

Communications Biology (Mar 2021)

A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

Atsuko Nakatsuka,
Satoshi Yamaguchi,
Jun Eguchi,
Shigeru Kakuta,
Yoichiro Iwakura,
Hitoshi Sugiyama,
Jun Wada

Affiliations

Atsuko Nakatsuka: Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Satoshi Yamaguchi: Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Jun Eguchi: Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shigeru Kakuta: Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University of Tokyo
Yoichiro Iwakura: Research Institute for Biomedical Sciences, Tokyo University of Science
Hitoshi Sugiyama: Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Jun Wada: Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

DOI: https://doi.org/10.1038/s42003-021-01902-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

Read online

Nakatsuka et al. discover that the adipokine vaspin contributes to maintaining proximal tubular cell (PTC) homeostasis by ameliorating organelle stress. They find that upon internalization, vaspin interacts with the heat shock protein HSPA1L and that the proteins cooperate to prevent metabolic stress-induced cellular injuries in PTCs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal