Repetitive magnetic stimulation induces plasticity of inhibitory synapses

Maximilian Lenz; Christos Galanis; Florian Müller-Dahlhaus; Alexander Opitz; Corette J. Wierenga; Gábor Szabó; Ulf Ziemann; Thomas Deller; Klaus Funke; Andreas Vlachos

doi:10.1038/ncomms10020

Nature Communications (Jan 2016)

Repetitive magnetic stimulation induces plasticity of inhibitory synapses

Maximilian Lenz,
Christos Galanis,
Florian Müller-Dahlhaus,
Alexander Opitz,
Corette J. Wierenga,
Gábor Szabó,
Ulf Ziemann,
Thomas Deller,
Klaus Funke,
Andreas Vlachos

Affiliations

Maximilian Lenz: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University
Christos Galanis: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University
Florian Müller-Dahlhaus: Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University
Alexander Opitz: Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Corette J. Wierenga: Division of Cell Biology, Faculty of Science, Utrecht University
Gábor Szabó: Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine
Ulf Ziemann: Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University
Thomas Deller: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University
Klaus Funke: Department of Neurophysiology, Medical Faculty
Andreas Vlachos: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University

DOI: https://doi.org/10.1038/ncomms10020
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Repetitive transcranial magnetic stimulation (rTMS) is widely used as a therapeutic tool yet its effect on inhibitory networks in the brain has not been studied. Here, the authors demonstrate that 10Hz rTMS specifically reduces dendritic inhibition onto pyramidal neurons accompanied by remodeling of postsynaptic gephyrin clusters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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