Assessment of serum fucose level among oral squamous cell carcinoma patients: A case-control study

Abstract

Background: Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the monosaccharides. Numerous illness conditions and cancers have been linked to increased levels of protein-bound fucose. Materials and Methods: In the current study, the serum fucose levels of patients with oral squamous cell carcinoma (OSCC) and healthy individuals were assessed and compared. The present study included a total of 30 OSCC patients and 30 healthy controls. The Winzler method was used to estimate the serum L-fucose levels using a spectrophotometer (Spectronic 20, Thermo Fisher Scientific, USA). Results: Age and sex had no effect on serum fucose levels. In contrast to healthy individuals, OSCC patients' mean serum fucose levels significantly increased. In conclusion, patients with OSCC can benefit from the use of serum fucose as an investigative biomarker.

Keywords

• biomarker
• malignancy
• oscc