Characteristics of BCR–ABL gene variants in patients of chronic myeloid leukemia

Abstract

Depending on breakpoints of rearrangement different types of BCR–ABL fusion protein can be generated in patients of chronic myeloid leukemia (CML). The aim of this study is to observe frequencies of major transcripts in CML patients by reverse transcriptase polymerase chain reaction (RT-PCR) and their hematological features at the time of presentation.

Keywords

• bcr–abl
• chronic myelyoid leukemia
• fusion transcript
• major breakpoint cluster region
• reverse transcriptase pcr