Does Vitamin D Level Affect Beta Cell Activity?

Abstract

Objective:The prevalence of vitamin D deficiency is ever-increasing throughout the world. Vitamin D deficiency is associated with disorders such as diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. This research study was carried out to assess serum vitamin D levels of patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose.Method:This study was carried out on 504 patients, who were newly diagnosed and did not receive medication before, aged 18 to 80 years, and who had type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Their fasting glucose, fasting insulin, total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein-cholesterol, triglyceride, 25(OH)D concentration, height and body weight measurements were analyzed retrospectively. Body mass index, homeostatic model assessment (HOMA) for insulin resistance and HOMA beta (B) values of the patients were calculated.Results:It was found that 89.9% of the patients with type 2 diabetes, 90.6% of the insulin resistance patients, 91.7% of the obesity patients and 94.1% of the impaired fast glucose patients had less than 30 ng/mL of serum 25(OH)D concentration. It was seen that the serum 25(OH)D concentrations of the patients were negatively correlated with their fasting insulin concentrations and HOMA B values, and positively correlated with their HDL-cholesterol levels.Conclusion:Based on this study, vitamin D deficiency was found to be common in the patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Serum 25(OH)D concentrations were correlated with the levels of fasting insulin, HDL-cholesterol, and beta-cell function.

Keywords

• homa b
• homa-ir
• insulin resistance
• obesity
• type 2 diabetes
• vitamin d