npj Biofilms and Microbiomes (Mar 2024)
Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer
- Aitor Blanco-Míguez,
- Sara Carloni,
- Cindy Cardenas,
- Carola Conca Dioguardi,
- Luca Lambroia,
- Giovanni Capretti,
- Gennaro Nappo,
- Alessandro Fugazza,
- Antonio Capogreco,
- Federica Armanini,
- Francesco Asnicar,
- Leonard Dubois,
- Davide Golzato,
- Paolo Manghi,
- Federica Pinto,
- Cristina Scuderi,
- Erminia Casari,
- Marco Montorsi,
- Andrea Anderloni,
- Maria Rescigno,
- Alessandro Repici,
- Alessandro Zerbi,
- Clelia Peano,
- Sabrina Tamburini,
- Roberto Rusconi,
- Nicola Segata
Affiliations
- Aitor Blanco-Míguez
- Department CIBIO, University of Trento
- Sara Carloni
- Department of Biomedical Sciences, Humanitas University
- Cindy Cardenas
- IRCCS Humanitas Research Hospital
- Carola Conca Dioguardi
- Institute of Genetics and Biomedical Research, UoS of Milan, National Research Council, Rozzano
- Luca Lambroia
- Department of Molecular and Translational Medicine, University of Brescia
- Giovanni Capretti
- Department of Pancreatic Surgery, IRCCS Humanitas Research Hospital
- Gennaro Nappo
- Department of Pancreatic Surgery, IRCCS Humanitas Research Hospital
- Alessandro Fugazza
- Department of Gastroenterology, IRCCS Humanitas Research Hospital
- Antonio Capogreco
- Department of Gastroenterology, IRCCS Humanitas Research Hospital
- Federica Armanini
- Department CIBIO, University of Trento
- Francesco Asnicar
- Department CIBIO, University of Trento
- Leonard Dubois
- Department CIBIO, University of Trento
- Davide Golzato
- Department CIBIO, University of Trento
- Paolo Manghi
- Department CIBIO, University of Trento
- Federica Pinto
- Department CIBIO, University of Trento
- Cristina Scuderi
- Microbiology and Virology Unit, IRCCS Humanitas Research Hospital
- Erminia Casari
- Microbiology and Virology Unit, IRCCS Humanitas Research Hospital
- Marco Montorsi
- Department of Biomedical Sciences, Humanitas University
- Andrea Anderloni
- Department of Gastroenterology, IRCCS Humanitas Research Hospital
- Maria Rescigno
- Department of Biomedical Sciences, Humanitas University
- Alessandro Repici
- Department of Biomedical Sciences, Humanitas University
- Alessandro Zerbi
- Department of Biomedical Sciences, Humanitas University
- Clelia Peano
- Institute of Genetics and Biomedical Research, UoS of Milan, National Research Council, Rozzano
- Sabrina Tamburini
- IEO, European Institute of Oncology IRCCS
- Roberto Rusconi
- Department of Biomedical Sciences, Humanitas University
- Nicola Segata
- Department CIBIO, University of Trento
- DOI
- https://doi.org/10.1038/s41522-024-00506-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 7
Abstract
Abstract Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.
