Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy

Mohamad Motaharinia; Kim Gerrow; Roobina Boghozian; Emily White; Sun-Eui Choi; Kerry R. Delaney; Craig E. Brown

doi:10.1038/s41467-021-26405-6

Nature Communications (Oct 2021)

Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy

Mohamad Motaharinia,
Kim Gerrow,
Roobina Boghozian,
Emily White,
Sun-Eui Choi,
Kerry R. Delaney,
Craig E. Brown

Affiliations

Mohamad Motaharinia: Division of Medical Sciences, University of Victoria
Kim Gerrow: Division of Medical Sciences, University of Victoria
Roobina Boghozian: Division of Medical Sciences, University of Victoria
Emily White: Division of Medical Sciences, University of Victoria
Sun-Eui Choi: Division of Medical Sciences, University of Victoria
Kerry R. Delaney: Department of Biology, University of Victoria
Craig E. Brown: Division of Medical Sciences, University of Victoria

DOI: https://doi.org/10.1038/s41467-021-26405-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

Read online

Stroke profoundly disrupts cortical excitability which impedes recovery, but how stroke affects inhibitory interneurons is poorly understood. Here, the authors show that functional impairments after stroke are associated with the disruption of a highly active subpopulation of interneurons expressing vasoactive intestinal peptide (VIP), which could be ameliorated by chemogenetic stimulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal