pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Ajkia Zaman Juthi; Fenfen Li; Bo Wang; Md Mofasserul Alam; Md Eman Talukder; Bensheng Qiu

doi:10.3390/pharmaceutics15030816

Pharmaceutics (Mar 2023)

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Ajkia Zaman Juthi,
Fenfen Li,
Bo Wang,
Md Mofasserul Alam,
Md Eman Talukder,
Bensheng Qiu

Affiliations

Ajkia Zaman Juthi: School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, China
Fenfen Li: Center for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, China
Bo Wang: School of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China
Md Mofasserul Alam: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230026, China
Md Eman Talukder: Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511400, China
Bensheng Qiu: Center for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, China

DOI: https://doi.org/10.3390/pharmaceutics15030816
Journal volume & issue: Vol. 15, no. 3
p. 816

Abstract

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Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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