Nature Communications (Apr 2020)
Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord
- Jun Zhang,
- Gopalakrishnan Chandrasekaran,
- Wenting Li,
- Dong-Young Kim,
- In Young Jeong,
- So-Hyun Lee,
- Ting Liang,
- Jin Young Bae,
- Isaac Choi,
- Hyuno Kang,
- Jin-Soo Maeng,
- Myeong-Kyu Kim,
- Taewon Lee,
- Seung Woo Park,
- Min Jung Kim,
- Hyung-Seok Kim,
- Hyunju Ro,
- Yong Chul Bae,
- Hae-Chul Park,
- Eun Young Choi,
- Seok-Yong Choi
Affiliations
- Jun Zhang
- Department of Biomedical Sciences, Chonnam National University Medical School
- Gopalakrishnan Chandrasekaran
- Department of Biomedical Sciences, Chonnam National University Medical School
- Wenting Li
- Department of Biomedical Sciences, Chonnam National University Medical School
- Dong-Young Kim
- Department of Biomedical Sciences, University of Ulsan College of Medicine
- In Young Jeong
- Department of Biomedical Sciences, Korea University
- So-Hyun Lee
- Department of Biomedical Sciences, Chonnam National University Medical School
- Ting Liang
- Department of Biomedical Sciences, Chonnam National University Medical School
- Jin Young Bae
- Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
- Isaac Choi
- Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University
- Hyuno Kang
- Division of Analytical Science, Korea Basic Science Institute
- Jin-Soo Maeng
- Research Group of Bioprocess Engineering, Korea Food Research Institute
- Myeong-Kyu Kim
- Department of Neurology, Chonnam National University Medical School
- Taewon Lee
- Division of Applied Mathematical Sciences, College of Science and Technology, Korea University
- Seung Woo Park
- Department of Internal Medicine, Yonsei University College of Medicine
- Min Jung Kim
- Department of Biological Sciences, Sookmyung Women’s University
- Hyung-Seok Kim
- Department of Forensic Medicine, Chonnam National University Medical School
- Hyunju Ro
- Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University
- Yong Chul Bae
- Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
- Hae-Chul Park
- Department of Biomedical Sciences, Korea University
- Eun Young Choi
- Department of Biomedical Sciences, University of Ulsan College of Medicine
- Seok-Yong Choi
- Department of Biomedical Sciences, Chonnam National University Medical School
- DOI
- https://doi.org/10.1038/s41467-020-15248-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Ependymal cells are supporting cells in the central nervous system. Here the authors elucidate a signalling axis in zebrafish spinal cord ependymal cells that is important for motile cilia assembly and maintenance, demonstrating that it depends on intercellular propagation of calcium ions via connexin 43.
