Nature Communications (Mar 2021)
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
- Carlota Rubio-Perez,
- Ester Planas-Rigol,
- Juan L. Trincado,
- Ester Bonfill-Teixidor,
- Alexandra Arias,
- Domenica Marchese,
- Catia Moutinho,
- Garazi Serna,
- Leire Pedrosa,
- Raffaella Iurlaro,
- Francisco Martínez-Ricarte,
- Laura Escudero,
- Esteban Cordero,
- Marta Cicuendez,
- Sara Ruiz,
- Genís Parra,
- Paolo Nuciforo,
- Josep Gonzalez,
- Estela Pineda,
- Juan Sahuquillo,
- Josep Tabernero,
- Holger Heyn,
- Joan Seoane
Affiliations
- Carlota Rubio-Perez
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Ester Planas-Rigol
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Juan L. Trincado
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Ester Bonfill-Teixidor
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Alexandra Arias
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Domenica Marchese
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Catia Moutinho
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Garazi Serna
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Leire Pedrosa
- Hospital Clinic, University of Barcelona and Institut d’Investigacio Biomedica August Pi i Sunyer (IDIBAPS)
- Raffaella Iurlaro
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Francisco Martínez-Ricarte
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Laura Escudero
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Esteban Cordero
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Marta Cicuendez
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Sara Ruiz
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Genís Parra
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Paolo Nuciforo
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Josep Gonzalez
- Hospital Clinic, University of Barcelona and Institut d’Investigacio Biomedica August Pi i Sunyer (IDIBAPS)
- Estela Pineda
- Hospital Clinic, University of Barcelona and Institut d’Investigacio Biomedica August Pi i Sunyer (IDIBAPS)
- Juan Sahuquillo
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Josep Tabernero
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Holger Heyn
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Joan Seoane
- Vall d Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- DOI
- https://doi.org/10.1038/s41467-021-21789-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
The use of CSF for diagnosis of metastatic brain tumors could be of clinical and patient benefit. Here the authors undertake a single-cell RNA analysis of CSF and brain to determine whether the phenotype in the CSF is reflective of the phenotype in the tumor.
