Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Dec 2019)
Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
- Daniela Perani,
- Leonardo Iaccarino,
- Andreas H. Jacobs,
- IMBI Brain Imaging Working Group,
- Adriaan A. Lammertsma,
- Agneta Nordberg,
- Albert D. Windhorst,
- Alexander Gerhard,
- Alexandra Winkeler,
- Andreas H. Jacobs,
- Anthony Gee,
- Bertrand Kuhnast,
- Christer Halldin,
- Daniela Perani,
- David Brooks,
- Elena Rodriguez‐Vieitez,
- Federico E. Turkheimer,
- Francisco López‐Picón,
- Gitte M. Knudsen,
- Johnny Vercouillie,
- Juha O. Rinne,
- Karl Herholz,
- Koen Van Laere,
- Andrea Varrone,
- Marie Joao Santiago‐Ribeiro,
- Matthias M. Herth,
- Michael A. Carroll,
- Sylvie Chalon,
- Michel Bottlaender,
- Oskar Hansson,
- Paul Edison,
- Rainer Hinz,
- Ronald Boellaard,
- Rosa Maria Moresco,
- Sabina Pappata
Affiliations
- Daniela Perani
- Vita‐Salute San Raffaele UniversityMilanItaly
- Leonardo Iaccarino
- Vita‐Salute San Raffaele UniversityMilanItaly
- Andreas H. Jacobs
- European Institute for Molecular Imaging, University of MünsterMünsterGermany
- IMBI Brain Imaging Working Group
- Adriaan A. Lammertsma
- Vita‐Salute San Raffaele UniversityMilanItaly
- Agneta Nordberg
- Vita‐Salute San Raffaele UniversityMilanItaly
- Albert D. Windhorst
- Vita‐Salute San Raffaele UniversityMilanItaly
- Alexander Gerhard
- Vita‐Salute San Raffaele UniversityMilanItaly
- Alexandra Winkeler
- Vita‐Salute San Raffaele UniversityMilanItaly
- Andreas H. Jacobs
- Vita‐Salute San Raffaele UniversityMilanItaly
- Anthony Gee
- Vita‐Salute San Raffaele UniversityMilanItaly
- Bertrand Kuhnast
- Vita‐Salute San Raffaele UniversityMilanItaly
- Christer Halldin
- Vita‐Salute San Raffaele UniversityMilanItaly
- Daniela Perani
- Vita‐Salute San Raffaele UniversityMilanItaly
- David Brooks
- Vita‐Salute San Raffaele UniversityMilanItaly
- Elena Rodriguez‐Vieitez
- Vita‐Salute San Raffaele UniversityMilanItaly
- Federico E. Turkheimer
- Vita‐Salute San Raffaele UniversityMilanItaly
- Francisco López‐Picón
- Vita‐Salute San Raffaele UniversityMilanItaly
- Gitte M. Knudsen
- Vita‐Salute San Raffaele UniversityMilanItaly
- Johnny Vercouillie
- Vita‐Salute San Raffaele UniversityMilanItaly
- Juha O. Rinne
- Vita‐Salute San Raffaele UniversityMilanItaly
- Karl Herholz
- Vita‐Salute San Raffaele UniversityMilanItaly
- Koen Van Laere
- Vita‐Salute San Raffaele UniversityMilanItaly
- Andrea Varrone
- Vita‐Salute San Raffaele UniversityMilanItaly
- Marie Joao Santiago‐Ribeiro
- Vita‐Salute San Raffaele UniversityMilanItaly
- Matthias M. Herth
- Vita‐Salute San Raffaele UniversityMilanItaly
- Michael A. Carroll
- Vita‐Salute San Raffaele UniversityMilanItaly
- Sylvie Chalon
- Vita‐Salute San Raffaele UniversityMilanItaly
- Michel Bottlaender
- Vita‐Salute San Raffaele UniversityMilanItaly
- Oskar Hansson
- Vita‐Salute San Raffaele UniversityMilanItaly
- Paul Edison
- Vita‐Salute San Raffaele UniversityMilanItaly
- Rainer Hinz
- Vita‐Salute San Raffaele UniversityMilanItaly
- Ronald Boellaard
- Vita‐Salute San Raffaele UniversityMilanItaly
- Rosa Maria Moresco
- Vita‐Salute San Raffaele UniversityMilanItaly
- Sabina Pappata
- Vita‐Salute San Raffaele UniversityMilanItaly
- DOI
- https://doi.org/10.1016/j.dadm.2019.02.004
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 327 – 332
Abstract
Abstract Introduction A rapid transition from a clinical‐based classification to a pathology‐based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi‐tracer molecular Brain Imaging, funded by the EU Joint Program ‐ Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods We consider current and future implications of adopting a pathology‐based framework for the use and development of positron emission tomography techniques. Results This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
Keywords