Frontiers in Psychiatry (Oct 2024)
The clock is ticking on schizophrenia: a study protocol for a translational study integrating phenotypic, genomic, microbiome and biomolecular data to overcome disability
- Giacomo Mercuriali,
- Lorenzo Lodde,
- Lorenzo Lodde,
- Pasquale Paribello,
- Pasquale Paribello,
- Jacopo Sapienza,
- Alice Corona,
- Alice Corona,
- Chiara Ave,
- Delia Pacini,
- Delia Pacini,
- Daniela Nocera,
- Carolina Corrias,
- Carolina Corrias,
- Sabrina El Kacemi,
- Sabrina El Kacemi,
- Michele D'Incalci,
- Ilaria Frau,
- Ilaria Frau,
- Elena Monzani,
- Flavia Valtorta,
- Flavia Valtorta,
- Donatella Congiu,
- Anna Meloni,
- Maria Scherma,
- Paola Fadda,
- Simona Dedoni,
- Carlotta Siddi,
- Stefania Sut,
- Stefano Dall’Acqua,
- Sofia Nasini,
- Benedetta Barzon,
- Alessio Squassina,
- Roberto Cavallaro,
- Roberto Cavallaro,
- Mirko Manchia,
- Mirko Manchia,
- Mirko Manchia,
- Claudia Pisanu,
- Marta Bosia,
- Marta Bosia,
- Stefano Comai,
- Stefano Comai,
- Stefano Comai,
- Stefano Comai
Affiliations
- Giacomo Mercuriali
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Lorenzo Lodde
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Lorenzo Lodde
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Pasquale Paribello
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Pasquale Paribello
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Jacopo Sapienza
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Alice Corona
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Alice Corona
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Chiara Ave
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Delia Pacini
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Delia Pacini
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Daniela Nocera
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Carolina Corrias
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Carolina Corrias
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Sabrina El Kacemi
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Sabrina El Kacemi
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Michele D'Incalci
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Ilaria Frau
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Ilaria Frau
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Elena Monzani
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Flavia Valtorta
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Flavia Valtorta
- School of Medicine, Vita-Salute San Raffaele University, Milan, Italy
- Donatella Congiu
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Anna Meloni
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Maria Scherma
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Paola Fadda
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Simona Dedoni
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Carlotta Siddi
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Stefania Sut
- Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
- Stefano Dall’Acqua
- Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
- Sofia Nasini
- Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
- Benedetta Barzon
- Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
- Alessio Squassina
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Roberto Cavallaro
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Roberto Cavallaro
- School of Medicine, Vita-Salute San Raffaele University, Milan, Italy
- Mirko Manchia
- Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Mirko Manchia
- Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy
- Mirko Manchia
- Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
- Claudia Pisanu
- Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, Italy
- Marta Bosia
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Marta Bosia
- School of Medicine, Vita-Salute San Raffaele University, Milan, Italy
- Stefano Comai
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Stefano Comai
- Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
- Stefano Comai
- Department of Biomedical Sciences, University of Padua, Padua, Italy
- Stefano Comai
- Department of Psychiatry, McGill University, Montreal, QC, Canada
- DOI
- https://doi.org/10.3389/fpsyt.2024.1451678
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundShared biological factors may play a role in both the cognitive deficits and the increased prevalence of metabolic syndrome observed in individuals with Schizophrenia (SCZ). These factors could entail disturbances in tryptophan (Trp) to both melatonin (MLT) and kynurenine (Kyn) metabolic pathways, as well as inflammation and alterations in the gut microbiome composition.MethodsThe present research project aims to investigate this hypothesis by recruiting 170 SCZ patients from two different recruitment sites, assessing their cognitive functions and screening for the presence of metabolic syndrome. Additionally, we plan to assess the impact of a 3-month cognitive remediation therapy on 30 of these patients. We will analyze clinical data alongside serum biomarkers and gene expression related to the Trp- to MLT and Kyn metabolic pathways, markers of inflammatory and composition of the gut microbiome. The association between Trp-MLT-Kyn levels, expression levels of selected genes, inflammatory markers and clinical phenotypes will be analyses in the context of general linear models.DiscussionThis project has the potential to identify some typical SCZ symptomatic clusters that will be more stringently associated with variations in the Trp-MLT-Kyn/inflammatory system and with a better response to cognitive remediation therapy. Moreover, in a future perspective, it may highlight a group of patients who may benefit from a pharmacological treatment aiming at reinstating the physiological Trp to MLT and Kyn system. Therefore, it has the potential to move research toward a personalized approach for SCZ management.
Keywords
