On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome

Abstract

Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other particles and call for more research into this pathway.

Keywords

• particulate matter air pollution
• NLRP3 inflammasome
• research needs