Química Nova (Jan 2013)

Trachylobane and kaurane diterpenes from Croton floribundus spreng

  • Paula Karina S. Uchôa,
  • José Nunes da Silva Jr.,
  • Edilberto Rocha Silveira,
  • Mary Anne S. Lima,
  • Raimundo Braz-Filho,
  • Letícia Veras Costa-Lotufo,
  • Ana Jérsia Araújo,
  • Manoel Odorico de Moraes,
  • Claudia do Ó Pessoa

DOI
https://doi.org/10.1590/S0100-40422013000600006
Journal volume & issue
Vol. 36, no. 6
pp. 778 – 782

Abstract

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A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.

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