Significant elevation of free itraconazole concentration at onset of adverse effects: A case report

Abstract

Abstract Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.

Keywords

• adverse effects
• free concentration
• hydroxyitraconazole
• Itraconazole
• therapeutic drug monitoring